HISTORY OF ORGANOPHOSPHORUS CHOLINESTERASE INHIBITORS & REACTIVATORS
نویسندگان
چکیده
منابع مشابه
Cholinesterase inhibitors and memory.
A consensus exists that cholinesterase inhibitors (ChEIs) are efficacious for mild to moderate Alzheimer's Disease (AD). Unfortunately, the number of non-responders is large and the therapeutic effect is usually short-lasting. In experimental animals, ChEIs exert three main actions: inhibit cholinesterase (ChE), increase extracellular levels of brain acetylcholine (ACh), improve cognitive proce...
متن کاملThe mode of recovery of cholinesterase activity in vivo after organophosphorus poisoning. 1. Erythrocyte cholinesterase.
Moerner, A. H. (1895). Skand. Arch. Phy8iol. 6, 332. Patte, J. C., Baldassaire, G. & Loret, J. (1958). Rev. franf. Eud. clin. biol. 3, 960. Peterson, H. A. & Sober, E. A. (1958). Fed. Proc. 17, 288. Popenoe, E. A. (1955). J. biol. Chem. 217, 61. Porter, K. R. & Tamm, I. (1955). J. biol. Chem. 212, 135. Prasad, A. S. & Flink, E. B. (1958). J. Lab. clin. Med. 51, 345. Rich, C. & DiFerrante, N. (1...
متن کاملThe mode of recovery of cholinesterase activity in vivo after organophosphorus poisoning. 2. Brain cholinesterase.
Previous investigators (Frawley, Hagan & Fitzhugh, 1952; Davison, 1955; Kewitz & Nachmansohn, 1957) have observed that the rate of recovery in vivo of inhibited brain true cholinesterase depended on which inhibitor was used. With diiwopropyl phosphorofluoridate (Frawley et al. 1952; Davison, 1955; Kewitz & Nachmansobn, 1957) recovery was slow, whereas with tetraethyl pyrophosphate (Davison, 195...
متن کاملOptimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents
Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative therapeutic approach because they neutralize OPs in bloodstream before they reach physiological target...
متن کاملRecovery of cholinesterase activity in mallard ducklings administered organophosphorus pesticides.
Oral doses of the organophosphorus pesticides acephate, dicrotophos, fensulfothion, fonofos, malathion, and parathion were administered to mallard ducklings (Anas platyrhynchos), and brain and plasma cholinesterase (ChE) activities were determined for up to 17 d after dosing. In vivo recovery of brain ChE activity to within 2 standard deviations of the mean activity of undosed birds occurred wi...
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ژورنال
عنوان ژورنال: Military Medical Science Letters
سال: 2015
ISSN: 0372-7025,0372-7025
DOI: 10.31482/mmsl.2015.023